Reading and rewriting protein modifications
The final layer of biological regulation is through a network of molecular signals relayed by chemical modifications on proteins, which influence how proteins interact with each other and function. Reading and rewriting the code relayed by protein modifications requires new innovations to systematically discover and measure where, when and how they occur, their regulatory outcomes, and the development of new cellular approaches to edit these modifications on target proteins. The overarching goal of the Woo lab is to understand how these small molecules influence protein function and biological signaling using chemical biology and proteomics approaches.
OUR RESEARCH
Research in the Woo Lab
We combine rational design of small molecules and proteins with chemical proteomics technology to tackle key challenges in the following focus areas:
Writing and erasing O-GlcNAc from Target Proteins in cells
E3 ligase biology And Protein damage response
Binding site mapping by ChEmical Proteomics
We invite you to learn more about our work through our recent publications and preprints.
THE TEAM
About Us
We are an energetic group of chemical biologists housed in the Conant Research Labs in the Department of Chemistry and Chemical Biology at Harvard University. We are passionate about understanding how nature uses chemical signals and how we can mimic them. Lab members have backgrounds in chemical biology, organic chemistry, chemical proteomics, molecular biology, and data analysis. We are also passionate about diversity and inclusion, and are actively supporting these initiatives in our community.
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